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The First and Only Patented A2M System

ALPHA2ACTIVE™ is an exciting advancement in orthopedic science resulting from years of osteoarthritis research. For the majority of people with pain, their arthritic joint or disc space houses more destructive enzymes than the body can handle. Alpha-2-Macroglobulin, more commonly referred to as A2M, is a master protease inhibitor that already exists in your blood and acts as a powerful inhibitor of cartilage breakdown.

A2M is a powerful inhibitor of cartilage catabolic factors and helps slow the progression of Osteoarthritis (OA) by preventing cartilage breakdown and cartilage loss. A2M has two binding sites, which capture proteases like a Venus fly-trap. Once captured, the bound A2M and proteases are eliminated from the joint or disc space through the body’s natural waste processes.

ALPHA2ACTIVETM, formerly APICTM A2M, is:

  • First and only system to centrifuge and filter plasma for isolated and concentrated autologous A2M
  • A2M Rich – 6 times the concentration found in blood
  • Low percentage of white blood cells eliminating unnecessary pain from the treatment
  • Settings for both Platelet-Rich Plasma and Platelet-Poor Plasma processing
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